Clinical Research

Miracle berries and their active substance, miraculin, have both been thoroughly used in clinical research with positive results. We have posted a sampling of the available research here, and we invite you to keep an eye on this page for more articles coming soon.

Cancer Related Research

a doctor and a patient smiling

“Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765360/

“Synsepalum dulcificum extracts exhibit cytotoxic activity on human colorectal cancer cells and upregulate c-fos and c-jun early apoptotic gene expression”:
https://www.researchgate.net/publication/322068964_Synsepalum_dulcificum_extracts_exhibit_cytotoxic_activity_on_human_colorectal_cancer_cells_and_upregulate_c-fos_and_c-jun_early_apoptotic_gene_expression

“Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: the CLINMIR Pilot Study” https://www.medrxiv.org/content/10.1101/2024.05.15.24307453v1.full

“Efficacy and Safety of Habitual Consumption of a Food Supplement Containing Miraculin in Malnourished Cancer Patients: the CLINMIR Pilot Study” https://www.researchgate.net/publication/380781713_Efficacy_and_Safety_of_Habitual_Consumption_of_a_Food_Supplement_Containing_Miraculin_in_Malnourished_Cancer_Patients_the_CLINMIR_Pilot_Study

“Anti-Angiogenesis and Anticancer Activities”: https://www.researchgate.net/publication/362696862_Identification_of_phenolics_from_miracle_berry_Synsepalum_dulcificum_leaf_extract_and_its_antiangiogenesis_and_anticancer_activities

“Evaluation of the antimicrobial and anticancer properties of the fruits of Synsepalum dulcificum (Sapotaceae)” https://miraburst.com/wp-content/uploads/2024/05/Evaluation_of_the_antimicrobial_and_anti.pdf

“Biological Activities of Miracle Berry Supercritical Extracts as Metabolic Regulators in Chronic Diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138767/

“Treatment of Taste Alterations in Chemotherapy Patients Using the ‘Miracle Fruit’”: Preliminary Analysis of a Pilot Study.” American Society of Clinical Oncology (ASCO):
http://meetinglibrary.asco.org/content/51247-74

“Pilot Study of ‘Miracle Fruit’ to Improve
Food Palatability for Patients Receiving Chemotherapy.” U.S. National Library of Medicine National Institutes of Health: http://www.ncbi.nlm.nih.gov/pubmed/23022943

Diabetes Related Research

man being finger pricked in doctor’s office

“Anti-Diabetic Properties of Synsepalum dulcificum and Its Potential Inclusion in Functional Yogurt”:
https://www.researchgate.net/publication/339197762_Anti-diabetic_properties_of_Synsepalum_dulcificum_and_its_potential_inclusion_in_functional_yogurt

“Improvement of Insulin Resistance by Miracle Fruit (Synsepalum dulcificum) in Fructose-Rich Chow-Fed Rats.” U.S. National Library of Medicine National Institutes of Health:
http://www.ncbi.nlm.nih.gov/pubmed/16941611

Modulatory Effects of Miracle Fruit Ethanolic Extracts on Glucose Uptake Through the Insulin Signaling Pathway in C2C12 Mouse Myotubes Cells”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418466/

“Antihyperglycemic and hepatoprotective properties of miracle fruit (Synsepalum dulcificum) compared to aspartame in alloxan-induced diabetic mice” https://www.researchgate.net/publication/344151973_Antihyperglycemic_and_hepatoprotective_properties_of_miracle_fruit_Synsepalum_dulcificum_compared_to_aspartame_in_alloxan-induced_diabetic_mice

“Anti-Diabetic Effect of the Leaf Extracts of the Miracle Berry”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747512/

“Antidiabetic Potential of the Leaf Extract of Miracle Berry Plant in Type 2 Diabetes”:
https://www.ncbi.nlm.nih.gov/pubmed/31374224

As a Taste Modifier

Phytochemicals, Nutritionals, and Antioxidant Properties of the Miracle Berry

colorful miracle berries on a bush

“Chemical Constituents and Their Antioxidant Activities”: https://www.researchgate.net/publication/346056975_Chemical_constituents_and_their_antioxidant_activities_from_the_leaves_of_Synsepalum_dulcificum

“Physicochemical Characterisation of Polysaccharides from the Seeds and Leaves of Miracle Fruit (Synsepalum dulcificum) and Their Antioxidant and α -Glucosidase Inhibitory Activities In Vitro”: 
https://www.researchgate.net/publication/315908404_Physicochemical_Characterisation_of_Polysaccharides_from_the_Seeds_and_Leaves_of_Miracle_Fruit_Synsepalum_dulcificum_and_Their_Antioxidant_and_a_-Glucosidase_Inhibitory_Activities_In_Vitro

“Phytochemicals, Nutritionals, and Antioxidant Properties of the Miracle Berry”: https://www.researchgate.net/publication/299418843_Phytochemicals_nutritionals_and_antioxidant_properties_of_miracle_fruit_Synsepalum_dulcificum

“Phytochemicals, Antinutrient, and Amino Acid Composition of the Miracle Berry”:
http://www.iosrjournals.org/iosr-jpbs/papers/Vol9-issue2/Version-5/E09252529.pdf

“Amino Acid Profile and Oxidazable Vitamin Content of Miracle Fruit”:
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.213

“Proximate and Micronutrient Analysis of Miracle Fruit”: https://www.academia.edu/7914076/PROXIMATE_AND_MICRONUTRIENT_ANALYSES_OF_SYNSEPALUM_DULCIFICUM_PULP

“Potential Nutritional Values of Skin, Pulp, and Seed of the Miracle Fruit”: https://pdfs.semanticscholar.org/5ce4/919e7543d26bb35665fcf6dae1b265bdeafb.pdf

“Proximate, Anti-Nutritional, and Phytochemical Composition of the Yellow Variety of the Miracle Fruit”:
https://www.researchgate.net/publication/333802758_Proximate_Anti-Nutritional_and_Phytochemical_Composition_of_the_Yellow_Variety_of_the_Synsepalum_Dulcificum_Miracle_Fruit_Berry

“Nutritionals, Anti-Nutritional, and Phytochemical Profile of the Leaves and Fruit of the Miracle Fruit”:
https://miraburst.com/wp-content/uploads/2020/01/Nutritionals-Anti-Nutritional-and-Phytochemical-Profile-of-the-Leaves-and-Fruit-of-the-Miracle-Fruit.pdf

“Contents of Phenolics and Flavonoids and Antioxidant Activities in Skin, Pulp, and Seeds of Miracle Fruit.” U.S. National Library of Medicine National Institutes of Health:
http://www.ncbi.nlm.nih.gov/pubmed/21535817

“Antioxidant-Rich Phytochemicals in Miracle Berry (Synsepalum dulcificum) and Antioxidant Activity of Its Extracts.” U.S. National Library of Medicine National Institutes of Health:
http://www.ncbi.nlm.nih.gov/pubmed/24491731

Toxicology Analysis of the Miracle Berry

miracle berries up close

“Effects of Methanol Extract of Synsepalum Dulcificum Pulp on Some Biochemical Parameters in Albino Rats”: https://academicjournals.org/proceeding/WANNPRES/article-full-text-pdf/E78B526

“Effect of Synsepalum Dulcificum Extract on Oxidative Stress and Hepatotoxicity Indices”:
https://miraburst.com/wp-content/uploads/2020/01/EFFECT-OF-SYNSEPALUM-DULCIFICUM-BERRY-EXTRACT-ON-OXIDATIVE-STRESS-AND-HEPATOTOXICITY-INDICES-FOLLOW.pdf

Non-Allergic Properties 

a logo that reads “Allergen-Free"

“Discarded Cross-Allergy Between Miracle Berry (Synsepalum dulcificum) and Peanut”: https://www.researchgate.net/publication/363905524_Discarded_cross-allergy_between_miracle_berry_Synsepalum_dulcificum_and_peanut

Other Health Benefits of the Miracle Berry

woman smiling while holding glass of juice

“Nutritional Benefits, Phytochemical Constituents, Ethnomedical Uses, and Biological Properties of the Miracle Fruit Plant”: https://www.researchgate.net/publication/348008847_Nutritional_benefits_phytochemical_constituents_ethnomedicinal_uses_and_biological_properties_of_Miracle_fruit_plant_Synsepalum_dulcificum_Shumach_Thonn_Daniell

“Influence of Miracle Berry Extract and Microencapsulated Lactococcus on the Antioxidant Activity and Probiotic Viability of Functional Yogurt”: https://www.researchgate.net/publication/344245651_Influence_of_miracle_fruit_Synsepalum_dulcificum_extract_and_microencapsulated_Lactococcus_lactis_Gh1_on_the_antioxidant_activity_and_probiotic_viability_of_functional_yogur

“Anti-Hyperuricaemic Effect of Miracle Berry – Ability of the Miracle Berry to Reduce Uric Acid in the Blood”: https://www.ncbi.nlm.nih.gov/pubmed/26821007

Who We Are

Since 2014, MiraBurst, founded by Dr. Emmanuel Asare, has proudly offered the world’s leading natural taste-modifying berry: the miracle berry. You can enjoy this natural sugar substitute in the form of our Mini Squares. Our miracle fruit products work by temporarily turning all sour or tart fruits, foods, and drinks sweet. As a result, they can help you to finally achieve your health goals that you previously struggled to achieve due to your sweet tooth. Order today!