Clinical Research

Miracle berries and their active substance, miraculin, have both been thoroughly used in clinical research with positive results. We have posted a sampling of the available research here, and we invite you to keep an eye on this page for more articles coming soon.

As a Taste Modifier

For Chemotherapy Taste Improvement

a doctor and a patient smiling

“Treatment of Taste Alterations in Chemotherapy Patients Using the ‘Miracle Fruit’”: Preliminary Analysis of a Pilot Study.” American Society of Clinical Oncology (ASCO):
http://meetinglibrary.asco.org/content/51247-74

Synsepalum dulcificum Memorial Sloan Kettering Cancer”: http://www.mskcc.org/cancer-care/herb/synsepalum-dulcificum

“Pilot Study of ‘Miracle Fruit’ to Improve
Food Palatability for Patients Receiving Chemotherapy.” U.S. National Library of Medicine National Institutes of Health: http://www.ncbi.nlm.nih.gov/pubmed/23022943

Diabetic Uses: Anti-Diabetic Properties

miracle berry mini-squares

“Anti-Diabetic Properties of Synsepalum dulcificum and Its Potential Inclusion in Functional Yogurt”:
https://www.researchgate.net/publication/339197762_Anti-diabetic_properties_of_Synsepalum_dulcificum_and_its_potential_inclusion_in_functional_yogurt

“Improvement of Insulin Resistance by Miracle Fruit (Synsepalum dulcificum) in Fructose-Rich Chow-Fed Rats.” U.S. National Library of Medicine National Institutes of Health:
http://www.ncbi.nlm.nih.gov/pubmed/16941611

“Anti-Diabetic Effect of the Leaf Extracts of the Miracle Berry”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747512/

“Antidiabetic Potential of the Leaf Extract of Miracle Berry Plant in Type 2 Diabetes”:
https://www.ncbi.nlm.nih.gov/pubmed/31374224

Modulatory Effects of Miracle Fruit Ethanolic Extracts on Glucose Uptake Through the Insulin Signaling Pathway in C2C12 Mouse Myotubes Cells”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418466/

Phytochemicals, Nutritionals, and Antioxidant Properties of the Miracle Berry

colorful miracle berries on a bush

“Chemical Constituents and Their Antioxidant Activities”: https://www.researchgate.net/publication/346056975_Chemical_constituents_and_their_antioxidant_activities_from_the_leaves_of_Synsepalum_dulcificum

“Physicochemical Characterisation of Polysaccharides from the Seeds and Leaves of Miracle Fruit (Synsepalum dulcificum) and Their Antioxidant and α -Glucosidase Inhibitory Activities In Vitro”: 
https://www.researchgate.net/publication/315908404_Physicochemical_Characterisation_of_Polysaccharides_from_the_Seeds_and_Leaves_of_Miracle_Fruit_Synsepalum_dulcificum_and_Their_Antioxidant_and_a_-Glucosidase_Inhibitory_Activities_In_Vitro

“Phytochemicals, Nutritionals, and Antioxidant Properties of the Miracle Berry”: https://www.researchgate.net/publication/299418843_Phytochemicals_nutritionals_and_antioxidant_properties_of_miracle_fruit_Synsepalum_dulcificum

“Phytochemicals, Antinutrient, and Amino Acid Composition of the Miracle Berry”:
http://www.iosrjournals.org/iosr-jpbs/papers/Vol9-issue2/Version-5/E09252529.pdf

“Amino Acid Profile and Oxidazable Vitamin Content of Miracle Fruit”:
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.213

“Proximate and Micronutrient Analysis of Miracle Fruit”: https://www.academia.edu/7914076/PROXIMATE_AND_MICRONUTRIENT_ANALYSES_OF_SYNSEPALUM_DULCIFICUM_PULP

“Potential Nutritional Values of Skin, Pulp, and Seed of the Miracle Fruit”: https://pdfs.semanticscholar.org/5ce4/919e7543d26bb35665fcf6dae1b265bdeafb.pdf

“Proximate, Anti-Nutritional, and Phytochemical Composition of the Yellow Variety of the Miracle Fruit”:
https://www.researchgate.net/publication/333802758_Proximate_Anti-Nutritional_and_Phytochemical_Composition_of_the_Yellow_Variety_of_the_Synsepalum_Dulcificum_Miracle_Fruit_Berry

“Nutritionals, Anti-Nutritional, and Phytochemical Profile of the Leaves and Fruit of the Miracle Fruit”:
https://miraburst.com/wp-content/uploads/2020/01/Nutritionals-Anti-Nutritional-and-Phytochemical-Profile-of-the-Leaves-and-Fruit-of-the-Miracle-Fruit.pdf

“Contents of Phenolics and Flavonoids and Antioxidant Activities in Skin, Pulp, and Seeds of Miracle Fruit.” U.S. National Library of Medicine National Institutes of Health:
http://www.ncbi.nlm.nih.gov/pubmed/21535817

“Antioxidant-Rich Phytochemicals in Miracle Berry (Synsepalum dulcificum) and Antioxidant Activity of Its Extracts.” U.S. National Library of Medicine National Institutes of Health:
http://www.ncbi.nlm.nih.gov/pubmed/24491731

Other Health Benefits of the Miracle Berry

woman smiling while holding glass of juice

“Anti-Angiogenesis and Anticancer Activities”: https://www.researchgate.net/publication/362696862_Identification_of_phenolics_from_miracle_berry_Synsepalum_dulcificum_leaf_extract_and_its_antiangiogenesis_and_anticancer_activities

“Nutritional Benefits, Phytochemical Constituents, Ethnomedical Uses, and Biological Properties of the Miracle Fruit Plant”: https://www.researchgate.net/publication/348008847_Nutritional_benefits_phytochemical_constituents_ethnomedicinal_uses_and_biological_properties_of_Miracle_fruit_plant_Synsepalum_dulcificum_Shumach_Thonn_Daniell

“Influence of Miracle Berry Extract and Microencapsulated Lactococcus on the Antioxidant Activity and Probiotic Viability of Functional Yogurt”: https://www.researchgate.net/publication/344245651_Influence_of_miracle_fruit_Synsepalum_dulcificum_extract_and_microencapsulated_Lactococcus_lactis_Gh1_on_the_antioxidant_activity_and_probiotic_viability_of_functional_yogur

“Synsepalum dulcificum extracts exhibit cytotoxic activity on human colorectal cancer cells and upregulate c-fos and c-jun early apoptotic gene expression”:
https://miraburst.com/wp-content/uploads/2024/02/AsianPacJTropBiomed83173-6635039_182550.pdf

“Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765360/

“Anti-Hyperuricaemic Effect of Miracle Berry – Ability of the Miracle Berry to Reduce Uric Acid in the Blood”: https://www.ncbi.nlm.nih.gov/pubmed/26821007

Toxicology Analysis of the Miracle Berry

miracle berries up close

“Effects of Methanol Extract of Synsepalum Dulcificum Pulp on Some Biochemical Parameters in Albino Rats”: https://academicjournals.org/proceeding/WANNPRES/article-full-text-pdf/E78B526

“Effect of Synsepalum Dulcificum Extract on Oxidative Stress and Hepatotoxicity Indices”:
https://miraburst.com/wp-content/uploads/2020/01/EFFECT-OF-SYNSEPALUM-DULCIFICUM-BERRY-EXTRACT-ON-OXIDATIVE-STRESS-AND-HEPATOTOXICITY-INDICES-FOLLOW.pdf

Non-Allergic Properties 

a logo that reads “Allergen-Free"

“Discarded Cross-Allergy Between Miracle Berry (Synsepalum dulcificum) and Peanut”: https://www.researchgate.net/publication/363905524_Discarded_cross-allergy_between_miracle_berry_Synsepalum_dulcificum_and_peanut

Who We Are

Since 2014, MiraBurst, founded by Dr. Emmanuel Asare, has proudly offered the world’s leading natural taste-modifying berry: the miracle berry. You can enjoy this natural sugar substitute in the form of our Mini Squares and our Freshly Frozen Miracle Berries. Our miracle fruit tablets work by providing a naturally clean and sweet taste to tart or sour drinks, fruits, and foods. As a result, they can help you to finally achieve your health goals that you previously struggled to achieve due to your sweet tooth. Order today!